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Journal of the Society for Gynecologic Investigation
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Effects of Magnesium Sulfate on the Fetal Heart Rate Response During Acute Hypoxemia in Goats

Hiroshi Sameshima, MD

Department of Obstetrics and Gynecology, Kagoshima City Hospital, Kagoshima; Department of Obstetrics and Gynecology, Miyazaki Medical College, Miyazaki; Department of Veterinary Medicine. Kogoshima University, Kagoshima, Japan; Department of Obstetrics and Gynecology, Miyazaki Medical College, 5200 Kihara, Kiyotake, Miyazaki, 889-16, Japan

Tsuyomu Ikenoue, MD

Masato Kamitomo, MD

Hiroshi Sakamoto, DVM

Department of Obstetrics and Gynecology, Kagoshima City Hospital, Kagoshima; Department of Obstetrics and Gynecology, Miyazaki Medical College, Miyazaki; Department of Veterinary Medicine. Kogoshima University, Kagoshima, Japan

Objective: The effects of magnesium sulfate on fetal heart rate (FHR) responses during acute hypoxemia in goats were investigated.

Methods: The FHR responses due to hypoxemia during magnesium sulfate infusion (Mg study) were compared with those during vehicle infusion (controls) in six chronically instrumented goat fetuses at 125-130 days' gestation.

Results: Four-hour infusions of magnesium sulfate significantly increased fetal plasma concentrations of magnesium from 2.3 to 6.5 mg/dL. During the hypoxemic period, the fetal arterial oxygen pressure was significantly decreased from 29.0 ± 2.5 to 14.6 ± 2.6 torr in the controls, and from 28.9 ± 3.9 to 13.7 ± 4.7 torr during the Mg study. Neither arterial carbon dioxide pressure nor pH was significantly altered. In the controls, FHR was significantly decreased by hypoxemia, accompanied by increases in variability. In the Mg study, FHR was not significantly decreased by hypoxemia. Acute hypoxemia also increased the FHR variability during magnesium infusion, which was significantly reduced compared with those in the control populationl.

Conclusion: Magnesium sulfate masks FHR-slowing responses during acute hypoxemia in fetal goats.

Key Words: fetal goats • magnesium sulfate • hypoxemia • fetal heart rate • variability

Journal of the Society for Gynecologic Investigation, Vol. 3, No. 5, 235-240 (1996)
DOI: 10.1177/107155769600300502
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