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Journal of the Society for Gynecologic Investigation
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The Effect of Insulin and Insulin-Like Growth Factors on Luteal Progesterone Secretion in the Rabbit

Josephine B. Miller, PhD

University of Illinois at Chicago, Department of Obstetrics and Gynecology, M/C 808 820 S. Wood Street, Chicago, IL 60612-7313

Charles Obasiolu, MD

Department of Obstetrics and Gynecology, University of Illinois at Chicago, Chicago, Illinois

Objective: The purpose of this study was to determine if insulin or insulin-like growth factors (IGF) either alone or in combination with estradiol (E2) could maintain progesterone secretion by rabbit luteal cells in culture.

Methods: Progesterone secretion was measured in media of luteal cell cultures incubated in serum-free media alone or containing E2 with or without added insulin, IGF-I or IGF-II.

Results: Progesterone production by rabbit luteal cells in culture fell precipitously in serum-free media containing E2, IGF-I, IGF-II, or insulin alone. However, when E2 was combined with insulin, IGF-I, or IGF-II, serum progesterone production was stimulatewd two- to fivefold above control levels.

Conclusion: There is an important synergism between insulin/IGF and E2 in regulating luteal steroidogenesis.

Key Words: Rabbit luteal cell cultures • estradiol • insulin • IGF-I • IGF-II

Journal of the Society for Gynecologic Investigation, Vol. 3, No. 5, 262-266 (1996)
DOI: 10.1177/107155769600300506
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