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Journal of the Society for Gynecologic Investigation, Vol. 3, No. 6, 350-353 (1996)
DOI: 10.1177/107155769600300609

Endothelin Plas±a Levels in Primary Amenorrheic Adolescents Before and After Estrogen Treatment

George C. Creatsas, MD, FACS

Division of Pediatric and Adolescent Gynecology, First Department of Obstetrics and Gynecology, "Alexandra" Hospital, University of Athens, Greece; 9 Kanari Str, 106 71 Athens, Greece

Ariande B. Malamitsi-Puchner, MD

Elsheikh A. Hassan, MD

Emmanuel B. Economou, PhD

Denis I. Aravantinos, MD

Division of Pediatric and Adolescent Gynecology, First Department of Obstetrics and Gynecology, "Alexandra" Hospital, University of Athens, Greece

Objective: We evaluated the effect of estrogen administration on endothelin (ET) secretion in primary amenorrheic (PA) adolescent girls.

Methods: Fifteen PA adolescents (ten hypergonadotropic, group A; five hypogonadotropic, group B) were treated with estrogen and progestogen tablets. A control group of ten healthy adolescents (group C) was included in the study. The ET 1-21, FSH, and LH plasma levels were tested before treatment (PrT) and immediately after the last estrogen tablet but before the progestogen administration (PoT).

Results: A statistically significant difference (P < .01) in ET 1-21 plasma values was found between PrT (9.66 ± 0.80 pmol/L) and PoT (7.56 ± 0.89 pmol/L) levels in group A cases. A similar reduction (P < .05) was recorded between PrT (8.06 ± 0.46 pmol/L) and PoT (5.59 ± 0.53 pmol/L) ET 1-21 plasma levels in group B cases. Endothelin 1-21 plasma PrT values were higher in both group A and B cases in comparison with controls (6.66 ± 0.44 pmol/L; P < .01, P < .1, respectively).

Conclusions: Estrogens administered to PA adolescents reduce ET 1-21 plasma levels in both hyper- and hypogonadotropism.

Key Words: Endothelins • primary amenorrhea • adolescence • estrogens


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