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Antepartum and Postpartum Thrombomodulin Levels in Preeclamptic and Normotensive Pregnancies

Joshua A. Copel, MD

Daniel W. Chan, PhD

Division of Maternal-Fetal Medicine, Department of Obstetrics and Gynecology, Yale University School of Medicine, New Haven, Connecticut; Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, Maryland USA

Objective: To determine whether changes in plasma levels of thrombomodulin from antepartum to postpartum reflect the postpartum regression of preeclampsia.

Methods: Twenty-four preeclamptic women and 34 healthy, normotensive women with singleton pregnancies were studied in the third trimester. Plasma levels of thrombomodulin in the antepartum and postpartum periods were measured by a two-site immunoenzymatic assay. Two-tailed Student t test and paired-comparison t test were used for statistical analyses. The results were expressed as mean ± standard error.

Results: Antepartum plasma thrombomodulin levels in preeclampsia were significantly higher than postpartum levels (71.3 ± 8.5 versus 55.5 ± 5.4 ng/mL; P = .006), which was not seen in the normotensive controls (49.9 ± 3.1 versus 44.2 ± 3.8 ng/mL; P > .05). Antepartum plasma levels of thrombomodulin in preeclamptic women were significantly higher than those in the normotensive controls (P = .01). However, postpartum plasma levels of thrombomodulin in preeclamptic women were not significantly higher than those in the normotensive controls (P > .05).

Conclusions: Significantly decreased postpartum plasma thrombomodulin levels in preeclamptic pregnancies strongly correspond to clinical postpartum regression of preeclampsia.

Key Words: Preeclampsia • thrombomodulin • antepartum • postpartum

Journal of the Society for Gynecologic Investigation, Vol. 4, No. 3, 135-137 (1997)
DOI: 10.1177/107155769700400304


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