Advanced Search

Journal Navigation

Journal Home

Subscriptions

Archive

Contact Us

Table of Contents

CiteULike is a free service for managing and discovering scholarly references - click here to get started.

Sign In to gain access to subscriptions and/or personal tools.
Journal of the Society for Gynecologic Investigation
This Article
Right arrow Full Text (PDF)
Right arrow References
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to Saved Citations
Right arrow Download to citation manager
Right arrowRequest Permissions
Right arrow Request Reprints
Right arrow Add to My Marked Citations
Citing Articles
Right arrow Citing Articles via Google Scholar
Right arrow Citing Articles via Scopus
Google Scholar
Right arrow Articles by Stark, R. I.
Right arrow Articles by Tropper, P. J.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Stark, R. I.
Right arrow Articles by Gerland, M.
Right arrow Articles by Daniel, S. S.
Right arrow Articles by Leung, K.
Right arrow Articles by Myers, M. M.
Right arrow Articles by Tropper, P. J.
Social Bookmarking
Add to CiteULike   Add to Complore   Add to Connotea   Add to Del.icio.us   Add to Digg   Add to Reddit   Add to Technorati   Add to Twitter  
What's this?

Fetal Cardiorespiratory and Neurobehavioral Response to Zidovudine (AZT) in the Baboon

Raymoand I. Stark, MD

Marianne Gerland, MB, ChB

Salha S. Daniel, PhD

Kenneth Leung, MS, EE

Michael M. Myers, PhD

Pamela J. Tropper, MD

Departments of Pediatrics, Anesthesiology, and Psychiatry, Columbia College of Physicians and Surgeons, Columbia University, New York, New York; Department of Obstetrics and Gynecology, Roosevelt St. Luke's Hospital Center, New York, New York

Objective: To evaluate the effects of intravenous of zidovudine (AZT) at a dose and duration of infusion comparable to that used clinically on parameters reflective of fetal well-being.

Methods: Thirteen chronically instrumented noninfected baboons were monitored during intravenous infusions of AZT. Fetal cardiorespiratory activity and neurobehavioral function were accessed with 4-48-hour infusion of AZT to ten mothers (0.5-2.1 mg/kg per hour) and three fetuses (2-6 mg/h), which resulted in fetal plasma concentrations of AZT of 194-3100 ng/ml.

Results: No significant differences were found in the mean values in control periods, before and after infusion with values during infusion for parameters of fetal heart rate and rate variability (n = 7), breathing activity (n = 8), electroencephalographic activity (n = 8), and behavioral state (n = 7). No correlations were found with drug level.

Conclusions: The abscence of associations between exposure of the fetal baboon to AZT and changes in parameters reflective of fetal condition suggests that comparable exposure of the human fetus during intravenous infusion of drug would not confound clinical monitoring used to assess fetal well-being. These findings supplement conclusions from clinical research in support of U.S. Public Health Service recommendations that intrapartum fetal monitoring be performed as clinically indicated, not specifically because pregnant patients are treated with intravenous AZT.

Key Words: Pregnancy • fetus • baboon • zidovudine • drug effect • fetal heart rate • blood pressure • fetal breathing activity • electroencephalogram • behavioral state • diurnal rhythm

Journal of the Society for Gynecologic Investigation, Vol. 4, No. 4, 183-190 (1997)
DOI: 10.1177/107155769700400403
Add to CiteULike CiteULike   Add to Complore Complore   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us   Add to Digg Digg   Add to Reddit Reddit   Add to Technorati Technorati   Add to Twitter Twitter    What's this?