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Journal of the Society for Gynecologic Investigation
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Red Cell Volume Determination Using a Stable Isotope of Chromium

Helayne M. Silver, MD

Mary Ann Seebeck, RN

Richard M. Cowett, MD

Kristine Y. Patterson, PhD

Claude Veillon, PhD

Departments of Obstetrics and Gynecology and Pediatrics, Brown University, Women and Infants' Hospital of Rhode Island, Providence, Rhode Island; Human Nutrition Research Center, U.S. Department of Agriculture, Beltsville, Maryland

Objective: To validate and improve a method of red cell volume determination by useof a stable isotope of chromium.

Methods: Twelve subjects were sequentially injected with red blood cells labeled with a stable isotope of chromium (53 Cr) and red blood cells labeled with radioisotopic chromium (51 Cr). Measurement of 53Cr dilution was by gas chromatography/mass spectrometry. Measurement of 51Cr dilution was by gamma counter.

Results: Comparison of the two methods let to results that differed on average by 34.5 ± 45.0 mL (1.8 ± 2.2%), 0.3 to 3.2%, 95% confidence interval.

Conclusion: Measurement of red cell volume by use of a stable isotope of chromium is accurate, with potential applications including measurement in pregnant women and children or other groups in whom exposure to radioisotopes is undesirable.

Key Words: Red cell volume • chromium • stable isotopes • blood volume

Journal of the Society for Gynecologic Investigation, Vol. 4, No. 5, 254-258 (1997)
DOI: 10.1177/107155769700400506
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