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Journal of the Society for Gynecologic Investigation
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Immunologic Features of Tumor-Infiltrating Lymphocytes and Peripheral Blood Lymphocytes in Overian Cancer Patients

Thomas Schöndorf, PhD

Heike Engle, MD

Christian M. Kurbacher, MD

Ursula Brenne, MD

Hannelore Kolhagen

Uwe-Jochen Göhring, MD, PhD

Anton Scharl, MD, PhD

Peter Mallmann, MD, PhD

Department of Gynecology and Obstetrics, University of Cologne, Cologne, Germany

Objective: To determine the immunologic characteristics of tumor infiltrating lymphocytes (TILs) in comparison with the corresponding peripheral blood lymphocytes (PBLs) of patients with overian cancer in order to detect specific antitumor-reactive-immunocompetent cells.

Methods: Tumor infiltrating lymphocytes and PBLs were phenotyped by their surface markers, cytokine pattern, proliferation rate, and cytotoxic ability.

Results: The phenotypes of both lymphocyte populations were very heterogeneous. Peripheral blood lymphocytes had a higher proliferative activity and cytotoxicity against natural killer-sensitive tumor cells than the coreesponding TILs. Furthermore TILs showed increased interleukin-4 expression whereas in PBLs, interferon-{gamma} production predominated.

Conclusion: Peripheral blood lymphocytes showed more potentially valuable behavioral characteristics than TILs. in the future we need to combine several methods in order to define immune cells with antitumor activity. These cells should be expanded ex vivo and stimulated specifically for use in the immunotherapy of overian cancer.

Key Words: Ovrian cancer • TILs • immunotherapy

Journal of the Society for Gynecologic Investigation, Vol. 5, No. 2, 102-107 (1998)
DOI: 10.1177/107155769800500209
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