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Role and Regulation of Nitric Oxide in the Uterus During Pregnancy and Parturition

Departments of Obstetrics and Gynecology and Anatomy and Neurosciences. The University of Texas Medical Branch, Galveston, Texas; 301 University Boulevard, Route 1062, Medical Research Building, Room 11.138, Galveston, TX 77555-1062 chyallam{at}tutmb.edu

Yuan-Lin Dong, Md, PhD

Pandu R. Gangula, PhD

Li Fang, MD

Departments of Obstetrics and Gynecology and Anatomy and Neurosciences. The University of Texas Medical Branch, Galveston, Texas

Objective: To review the English-language literature as it relates to the role and regulation of uterine nitric oxide (NO) during pregnancy and parturition, special emphasis being placed on the interactions of NO with other uterotonic agents. Methods: A thorough literature review of the English-language literature using a Medline search was performed.

Results: Current data support the view that NO is generated in the uterus and inhibits uterine contractility. Gestation, parturition, steroid hormones, and prostaglandins modulate both the generation and the effects of NO on the uterus. The changes in NO and its effects are consistent with the theory that NO plays a role in uterine quiescence during pregnancy. A change in this system at term or preterm could play a role in inhibition of labor and delivery.

Conclusion: Uterine NO may play a role in maintaining uterine quiescence during pregnancy.

Key Words: Nitric oxide • nitric oxide synthase • prostaglandin • uterus • pregnancy • parturition • steroid hormones

Journal of the Society for Gynecologic Investigation, Vol. 5, No. 2, 58-67 (1998)
DOI: 10.1177/107155769800500202


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