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Journal of the Society for Gynecologic Investigation, Vol. 5, No. 3, 114-121 (1998)
DOI: 10.1177/107155769800500302

A Role for Hepatocyte Growth Factors/Scatter Factor in Regulating Normal and Neoplastic Cells of Reproductive Tissues

Melissa Lail-Trecker, PhD

Rita Gulati, MD

Department of Obstetrics and Gynecology, University of Connecticut Health Center, Farmington, Connecticut

John J. Peluso, PhD

Department of Obstetrics and Gynecology, University of Connecticut Health Center, Farmington, CT 06030 peluso{at}nso2.uchc.edu

Objective: To review data regarding the expression, function, and signal transduction pathways associated with hepatocyte growth factor/scatter factor (HGF/SF) as related to normal and neoplastic cells of reproductive tissues.

Methods: Studies involving HGF/SF were reviewed and the data were summarized.

Results: Hepatocyte growth factor/scatter factor is generally expressed within the stromal components of the testis, prostate, placenta, mammary gland, uterine endometrium, and ovary. The receptor for HGF/SF, c-met, is expressed in the epithelial cells of these tissues. Ligand activation of c-met results in its autotyrosine phosphorylation and the subsequent stimulation of numerous signal transduction pathways. Which pathways are activated determine in part the effect that HGF/SF has on a specific tissue. Hepatocyte growth factor/scatter factor can promote a variety of biologic responses including mitosis, motogenesis (ie, cell movement), differentiation, and apoptosis. In addition, both HGF/SF and c-met continue to be expressed during the neoplastic transformation of cells from these reproductive tissues.

Conclusion: Hapatocyte growth factor/scatter factor plays an important role in regulating the physiologic function of several reproductive tissues and may also be involved in the oncogenesis of cells within these tissues.

Key Words: Hepatocyte growth factor • c-met • testis • prostate • placenta


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