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Expression of the ErbB Family of Receptors in Ovarian Cancer

Young Mi Lee, MD

Craig Niederberger, MD

Departments of Obstetrics and Gynecology and Urology, University of Illinois at Chicago, College of Medicine. Chicago. Illinois

John V. Ilekis, PhD

Division of Reproductive Endocrinology, Department of Obstetrics and Gynecology (MC 808). University of Illinois at Chicago, College of Medicine, 820 South Wood St., Chicago, IL 60621 ilekis{at}uic.edu

Objective: To characterize the relative levels of the ErbB family of receptors and their relationship to one another in ovarian cancer.

Methods: A total of 17 serous cystadenocarcinonas were analyzed for epidermal growth factor receptor (EGF-R or ErbB-1) and ErbB-2, ErB-3, and ErbB-4 receptor expression by Western blot analysis. Receptor levels were quantified by densitometry and expressed as relative densitometry units nomalized to the level of -tubulin. Linear regression analysis was used to analyze receptor group differences. A value of P .05 was considered statistically significant.

Results: All 17 tumors expressed detectable levels of EGF-R, ErbB-2, and ErbB-3, but ErbB-4 expression was not detected. EGF-R levels correlated with ErbB-2 (r = .70, P < .01) and ErbB-3 (r= .52, P < .05) levels. The highest correlation was obtained between the levels of ErbB-2 and ErbB-3 (r = 0.81, P < .001).

Conclusion: This study indicates an association between the levels of ErbB receptor family members in ovarian cancer. This association suggests that one or more coordinated regulatory mechanisms may be involved in determining their relative expression levels to one another.

Key Words: Ovarian cancer • ErbB • growth factor receptors

Journal of the Society for Gynecologic Investigation, Vol. 5, No. 3, 161-165 (1998)
DOI: 10.1177/107155769800500310


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