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Chromosomal Abnormalities in Ectopic Pregnancy Chorionic Villi

Divisions of Reproducive Endocrinology and Clinical Genetics, Department of Obstetrics and Gynecology, University of South Carolina School of Medicine, Columbia, South Carolina; Division of Maternal-Fetal Medicine, Department of Obstetics and Gynecology, East Tennessee State University, P.O. Box 70569, Johnson City, TN 37614

Gordon C. Wolf, MD,PhD

Robert G. Best, PhD

Divisions of Reproducive Endocrinology and Clinical Genetics, Department of Obstetrics and Gynecology, University of South Carolina School of Medicine, Columbia, South Carolina

Objective: To evaluate the incidence of chromosomal abnormalities in ectopic pregnancy chorionic villi.

Methods: A prospective study of patients with the diagnosis of ectopic pregnancy was conduced, with chorionic villi obtained at the time of surgical therapy cultured and analyzed for kartotype. Review of the patient's medical record ultrasound evaluation was then completed findings correlated with karyotype results.

Results: Twenty-two patients undergoing surgery for the diagnosis of ectopic pregnancy yielded chorionic villi for culture. Successful culture was performed in 21 patients, with 3 (14%) revealing abnormal karyotypes. Review of the medical record ultrasound results consistent with fetal development or a gestational sac in 15 of 18 patients with normal chromosomal analysis. Three of 6 patients without fetal development yielded abnormal chromosomal findings.

Conclusion: Our results confirm that a high degree of success can be achieved in the karyotype analysis of ectopic pregnancy chorionic villi and that these conceptuses have a rate of abnormality similar to that reported for intrauterine gestations. Our data further suggest that when a gestational sac or fetal pole is identified by ultrasound, there is usually karyotype.

Key Words: Ectopic pregnancy • karyotype • ultrasound

Journal of the Society for Gynecologic Investigation, Vol. 5, No. 6, 324-326 (1998)
DOI: 10.1177/107155769800500608


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