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Journal of the Society for Gynecologic Investigation
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Central Hemodynamic Effects of an Oxytocin Receptor Antagonist (Atosiban) in the Isolated, Perfused Rat Heart

John M. Thorp, Jr, MD

Department of Obstetrics and Gynecology and Anesthesiology, University of North Carolina School of Medicine, Chapel Hill, North Carolina; thorp{at}med.unc.edu

David Mayer, MD

Jeffrey A. Kuller, MD

Department of Obstetrics and Gynecology and Anesthesiology, University of North Carolina School of Medicine, Chapel Hill, North Carolina

Objective: Atosiban is a selective oxytocin receptor antagonist capable of inhibiting oxytocin-induced contractility of the uterus. Trials of this agent in intact animals and women as a tocolytic agent for preterm labor have shown atosiban to be devoid of cardiac effects. This is in contast to other tocolytic agents, which have profound hemodynamic effects. We conducted this study to determine the cardiac effects of atosiban in the isolated, perfused rat heart model.

Methods: hearts were excised from 60 female Sprague-Dawley rats and attached to a Langendorff apparatus. Left ventricular systolic pressure, heart rate, and contractility were measured. Hearts from half of the animals were exposed serially to 300 µg/min, 600 µg/min, and 1200 µg/min of atosiban. The remaining hearts formed the control group and were exposed to aerated Krebs solution.

Results: There were no significant differences between hearts exposed to atosiban and hearts within the control group for heart rate, left ventricular systolic pressure, and contractility. P values ranged from .12 to .73.

Conclusions: Using a classic physiologic model to study cardiac performance and drug effects, we were unable to detect any central hemodynamic effects of atosiban. This is in contrast to oxytocin, which we previously studied and found negative chronotropic and positive ionotropic effects.

Key Words: Antagonist • tocolytic drug

Journal of the Society for Gynecologic Investigation, Vol. 6, No. 4, 186-187 (1999)
DOI: 10.1177/107155769900600404
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