Journal of the Society for Gynecologic Investigation

 

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Journal of the Society for Gynecologic Investigation, Vol. 6, No. 6, 285-292 (1999)
DOI: 10.1177/107155769900600602

Reviews

Cyclooxygenases in Reproductive Medicine and Biology

Douglas A. Kniss, PhD

Department of Obstetrics and Gynecology, Laboratory of Perinatal Research, The Ohio State University, College of Medicine and Public Health, Columbus, Ohio; kniss.1{at}osu.edu

This review focuses on the role of cyclooxygenases in reproductive medicine and biology. The cyclooxygenase enzymes catalysis the role-limiting reactions for prostaglandins and thromboxame synthesis. Two separate isoforms, COX-1 and COX-2, are present, and differences in their roles are discussed in the context of inflammation and parturition.

Key Words: Cyclooxygenase • COX-1 • COX-2 • prostaglandins • parturition • pregnancy


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