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Journal of the Society for Gynecologic Investigation
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Adrenomedullin Levels in Normal and Preeclamptic Pregnancy at Term

Michele R. Lauria, MD

Department of Obstetrics and Gynecology, Division and Maternal-Fetal Medicine, Wayne State University, Detroit, Michigan; Dartmouth Hitchcock Medical Center, One Medical Center Drive, Lebanon, NH 03756 michele.lauria{at}hitchcock.org

Cynthia A. Standley, PhD

Yoram Sorokin, MD

Frank D. Yelian, MD, PhD

David B. Cotton, MD

Department of Obstetrics and Gynecology, Division and Maternal-Fetal Medicine, Wayne State University, Detroit, Michigan

Objective: To describe maternal plasma levels of adrenomedullin (AM), a hypotensive and natriuretic peptide, in normal and preeclamptic women at term.

Study design: Maternal plasma AM levels were determined in 13 preeclamptic and 15 normotensive primigravidas by radioimmunoassay. Plasma samples were obtained with the patients in the lateral recumbent position before the administration of any medications.

Results: Women with preeclampsia had significantly elevated AM levels when compared with normotensive controls (42.3 ± 10.5 pg/mL versus 16.9 ± 3.1 pg/mL, P < .011).

Conclusion: In this pilot study, AM levels were significantly increased at term in preeclamptic women.

Key Words: Preeclampsia • adrenomedullin • vasoactive agents

Journal of the Society for Gynecologic Investigation, Vol. 6, No. 6, 318-321 (1999)
DOI: 10.1177/107155769900600607
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