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Journal of the Society for Gynecologic Investigation
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Estrogen Receptor Knock-Out Mice: Molecular and Endocrine Phenotypes

Kenneth S. Korach, PhD

Environmental Disease Medical Program, NIH-NIEHS, Research Triangle Park, North Carolina

Using gene-targeting techniques, transgenic, knock-out (KO) mice, homozygous for the disrupted estrogen receptor {alpha} ({alpha}ERKO) and ß gene (ßERKO) have been produced. Estrogen receptor (ER) ß expression does not appear to be dependent on ER {alpha} expression. Progesterone receptor (PR) mRNA is detected in {alpha}ERKO mice and appears to have both estrogen-independent and -dependent gene regulation. The phenotypic differences in {alpha}ERKO and ßERKO mice are described. Additional studies will further define the specific roles of ER {alpha} and ER ß in various tissues.

Key Words: Estrogen receptor knock-out mice • {alpha}ERKO • ßERKO • transgenic mice • estrogen receptor {alpha} and ß • gene-targeting techniques

Journal of the Society for Gynecologic Investigation, Vol. 7, No. 1 suppl, S16-S17 (2000)
DOI: 10.1177/107155760000700106
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