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Journal of the Society for Gynecologic Investigation
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Reproductive Functions of the Progesterone Receptor

Orla M. Conneely, PhD

Department of Cell Biology, Baylor College of Medicine, Debakey Bldg., M-513A, Houston, TX 77030

John P. Lydon, PhD

Francesco De Mayo, PhD

Bert W. O'Malley, PhD

Department of Cell Biology, Baylor College of Medicine, Houston, Texas

Progesterone plays a central coordinate role in regulating reproductive events associated with the establishment and maintenance of pregnancy including ovulation, uterine and mammary gland development and tumorigenesis, and neurobehavioral expression associated with sexual responsiveness. The effects of progresterone are mediated by two receptor proteins (PR), termed A and B, that arise from a single gene and act as ligand-activated transcription factors to regulate the expression of reproductive target genes. Null mutation of both proteins in mice leads to pleiotropic reproductive abnormalities. This review summarizes the structure and functional properties of the PR isoforms and how functional differences between these proteins are likely to impact on the overall physiologic role of the receptor in reproductive systems.

Key Words: Progresterone • progesterone receptor A • progesterone receptor B • progesterone receptor knock-out mice

Journal of the Society for Gynecologic Investigation, Vol. 7, No. 1 suppl, S25-S32 (2000)
DOI: 10.1177/107155760000700109
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