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DOI: 10.1177/107155760000700113 Clinical Uses of AntiprogestogensDepartment of Obsterics/Gynecology, University of Edinburgh, 37 Chalmers Street, Edinburgh, Scotland EH 39EW United Kingdom Progesterone is essential to the establishment and maintenance of pregnacy. Compounds that inhibit the synthesis of progesterone, or antagonize progesterone action, have multiple effects including the induction of abortion, labor induction, contraception, and cervical riening. They also may be used in the treatment of endometriosis, fibromyomata, meningiomas, Cushing syndrome, and glaucoma. Antiprogesterone compounds will play important roles in manipulating reproductive function for fertility control and in the treatment of hormone-dependent disease. This article reviews the potential of antiprogesterone compounds.
Key Words: Progesterone progesterone antagonists abortion labor induction contraception cervical ripening endometriosis fibromyomata meningiomas
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