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Journal of the Society for Gynecologic Investigation
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Clinical Uses of Antiprogestogens

David T Baird, MD, DSc

Department of Obsterics/Gynecology, University of Edinburgh, 37 Chalmers Street, Edinburgh, Scotland EH 39EW United Kingdom

Progesterone is essential to the establishment and maintenance of pregnacy. Compounds that inhibit the synthesis of progesterone, or antagonize progesterone action, have multiple effects including the induction of abortion, labor induction, contraception, and cervical riening. They also may be used in the treatment of endometriosis, fibromyomata, meningiomas, Cushing syndrome, and glaucoma. Antiprogesterone compounds will play important roles in manipulating reproductive function for fertility control and in the treatment of hormone-dependent disease. This article reviews the potential of antiprogesterone compounds.

Key Words: Progesterone • progesterone antagonists • abortion • labor induction • contraception • cervical ripening • endometriosis • fibromyomata • meningiomas

Journal of the Society for Gynecologic Investigation, Vol. 7, No. 1 suppl, S49-S52 (2000)
DOI: 10.1177/107155760000700113
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