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Journal of the Society for Gynecologic Investigation
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Magnesium Sulfate and Fetal Plasma Concentrations of Epinephrine, Norepinephrine, and Vasopressin in Response to Acute Hypoxemia in Goats

Hiroshi Sameshima, MD, PhD

Perinatal Center and Department of Obstetrics and Gynecology, Miyazaki Medical College, Miyazaki; Department of Obstetrics and Gynecology, Kagoshima City Hospital, Kigoshima; Department of Veterinary Medicine, Kagoshima University, Kagoshima, Japan hsameshima{at}fc.miyazaki-med.ac.jp

Shigeki Tanaka, MD

Masato Kamitomo, MD

Tsuyomu Ikenoue, MD

Hiroshi Sakamoto, MD, DVM

Perinatal Center and Department of Obstetrics and Gynecology, Miyazaki Medical College, Miyazaki; Department of Obstetrics and Gynecology, Kagoshima City Hospital, Kigoshima; Department of Veterinary Medicine, Kagoshima University, Kagoshima, Japan

Objective: We measured fetal plasma concentrations of epinephrine, norepinephrine, and vasopressin during acute hypoxemia in goats and tested whether hypermagnesemia altered these endocrine responses.

Methods: Five chronically catheterized goat fetuses at 124-129 days' gestation were used. After 4 hours of infusion (magnesium or vehicle as controls), 30 minutes of hypoxemia was induced by infusing nitrogen gas through a maternal tracheal catheter. Fetal plasma concentrations of epinephrine, norepinephrine, and vasopressin were measured before and during hypoxemia. Both magnesium sulfate and vehicle infusions were performed in each animal. Repeated-measures analysis of variance (ANOA) and two-way ANOVA with post hoc test were used to determine statistical significance.

Results: During hypoxemia, fetal Po2 decreased significantly from 30 to 14 mmHg with no significant changes in fetal pH or Pco2 in both groups. Fetal heart rate was reduced significantly by hypoxemia, but to a lesser extent in the magnesium group (change in decrease in fetal heart rate: 41 beats per minute [bp] in controls versus 26 bpm with magnesium). Mean blood pressure did not change significantly during hypoxemia in both groups. Fetal plasma concentrations of epinephrine, norepinephine, and vasopressin significantly increased from the prehypoxemic values both with magnesium and in controls. There were no significant differences in these hormone concentrations between magnesium and the controls.

Conclusion: Magnesium sulfate had no effect on fetal plasma concentrations of vasopressin, epinephrine, and norepinephrine during acute hypoxemia.

Key Words: Epinephrine • fetal goats • hypoxemia • magnesium sulfate • norepinephrine • vasopressin

Journal of the Society for Gynecologic Investigation, Vol. 7, No. 6, 328-332 (2000)
DOI: 10.1177/107155760000700602
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