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Maternal Basic Fibroblast Growth Factor Serum Levels Are Associated With Pregnancy-Induced Hypertension

Lukas Hefler, MD

Harald Zeisler, MD

Christian Schatten, MD

Peter Husslein, MD

Department of Obsterics and Gynecology, University of Vienna Medical School, Vienna, Austria; Department of Obsterics and Gynecology, Baylor College of Medicine, Houston, Texas

Clemens Tempfer, MD

Department of Obsterics and Gynecology, Baylor College of Medicine, Houston, Texas; Departments of Obstetrics and Gynecology, Vienna University Medical School, A-1090 Vienna, Währinger Gürtel 18-20, Austria clemens.tempfer{at}akh-wien.ac.at

Objective: To test the hypothesis that serum levels of basic fibroblast growth factor (bFGF) are altered among women with pregnancy-induced hypertension (PIH) and are associated with disease severity.

Methods: We evaluated serum levels of bFGF in 46 women with PIH, 46 age- and parity-matched healthy pregnant women, and 46 healthy nonpregnant controls. Enzyme-liked immunosorbent asseays were used to determine serum levels of bFGF. Results were correlated to clinical data.

Results: The overall mean serum levels of bFGF were 3.2 (standard deviation [SD] 9.3) µmol/L. Mean serum levels of bFGF in normal controls, healthy pregnant women, and women with PIH were O (SD O) µmol/L, 2.6 (SD 6.3) µmol/L, and 6.8 (SD 13.8) µmol/L, respectively (P = .003) for normal controls compared with healthy pregnant women and P <.001 for healthy pregnant women compared with women with PIH). In a univariate logistic regression model bFGF showed a significant influence on the odds of presenting with PIH compared with healthy pregnant women (p = .002). The mean serum levels of bFGF in women with severe PIH and in women with mild PIH were 4.4 (SD 10.6) µmol/L and 9.5 (SD 17.3) µmol/L, respectively (P = .1). IN a univariate logistic regression model bFGF did not reveal a significant infuence on the odds of developing severe PIH (P = .3).

Conclusions: Elevated serum levels of bFGF are associated with PIH, but aFGF does not seem to be a useful prognostic parameter for severe PIH.

Key Words: bFGF • pregnancy-induced hypertension • serum

Journal of the Society for Gynecologic Investigation, Vol. 8, No. 1, 24-26 (2001)
DOI: 10.1177/107155760100800104


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