Journal of the Society for Gynecologic Investigation

 

Advanced Search

Journal Navigation

Journal Home

Subscriptions

Archive

Contact Us

Table of Contents

http://mc.manuscriptcentral.com/rsci

Click here for more information

Sign In to gain access to subscriptions and/or personal tools.
This Article
Right arrow Full Text (PDF)
Right arrow References
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to Saved Citations
Right arrow Download to citation manager
Right arrowRequest Permissions
Right arrow Request Reprints
Right arrow Add to My Marked Citations
Citing Articles
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Yan, C.
Right arrow Articles by Matzuk, M. M.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us   Add to Digg   Add to Reddit   Add to Technorati  
What's this?
Journal of the Society for Gynecologic Investigation, Vol. 8, No. 1 suppl, S30-S33 (2001)
DOI: 10.1177/107155760100800110
© 2001 SAGE Publications

Transgenic Models of Ovarian Failure

Changning Yan, MS

Departments of Pathology, Molecular and Human Genetics, and Molecular and Cellular Biology, Baylor College of Medicine, Houston, Texas

Martin M. Matzuk, MD,PhD

Departments of Pathology, Molecular and Human Genetics, and Molecular and Cellular Biology, Baylor College of Medicine, Houston, Texas; Departments of Pathology, Molecular and Cellular Biology, and Molecular and Human Genetics, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030; mmatzuk{at}bcm.tmc.edu

Reproductive development and function are a complex process requiring the coordinate interactions of multiple extragonadal and intragonadal factors. Peptide hormones from the hypothalamus (eg, gonadotropin releasing hormone) and the pituitary (eg, follicle stimulating hormone, luteinizing hormone, oxytocin) as well as growth factors and steroids from the gonads (eg, inhibins, growth differentiation factor-9, progesterone, estradiol, testosterone) play key functions in regulating specific aspects of reproduction. Our laboratory used spontaneous mutant mice and transgenic mouse models to address the essential roles of some of these factors in the propagation of the mammalian species. This review summarizes some of our initial studies to understand this process.

Key Words: Transgenic mice • transforming growth factor • folliculogenesis • female infertility


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us   Add to Digg Digg   Add to Reddit Reddit   Add to Technorati Technorati    What's this?