Journal of the Society for Gynecologic Investigation

 

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Journal of the Society for Gynecologic Investigation, Vol. 8, No. 3, 169-173 (2001)
DOI: 10.1177/107155760100800308

Placental Expression and Serum Levels of Cytokeratin-18 Are Increased in Women With Preeclampsia

Lukas A. Hefler, MD

Departments of Obstetrics and Gynecology and Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas; Departments of Obstetrics and Gynecology and Medical Computer Sciences, University of Vienna Medical School, Vienna, Austria l_hefler{at}hotmail.com

Clemens B. Tempfer, MD

Dagmar Bancher-Todesca, MD

Christian Schatten, MD

Peter Husslein, MD

Georg Heinze, PhD

Anthony R. Gregg, MD

Departments of Obstetrics and Gynecology and Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas; Departments of Obstetrics and Gynecology and Medical Computer Sciences, University of Vienna Medical School, Vienna, Austria

Objective: To evaluate placental expression and serum cytokeratin-18 in women with preeclampsia.

Methods: Serum cytokeratin-18 was evaluated in 44 women with preeclampsia and 44 healthy pregnant women using an immunoradiometric assay. Placental expression of cytokeratin-18 was investigated in specimens from 23 women with preeclampsia and 20 healthy pregnant women by immunohistochemistry.

Results: Median serum cytokeratin-18 in women with preeclampsia and healthy pregnant women was 106.7 and 76.0 U/L, respectively (P =.02). Among women with preeclampsia, serum cytokeratin-18 was significantly associated with severity of disease (P =.001) and showed a sensitivity (standard error) and specificity (standard error) of 85% (7%) and 65% (12%),respectively. In placental specimens, the cytoplasm of the syncytiotrophoblast stained positive for cytokeratin-18 with strong and widespread staining in 83% and 45% of placental specimens of women with preeclampsia and healthy pregnant women, respectively (P =.01).

Conclusion: Elevated serum cytokeratin-18 values are associated with disease severity in women with preeclampsia. OUr data provide additional evidence that the placenta might be the source of the elevated serum cytokeratin-18 values in women with preeclampsia.

Key Words: Preeclampsia • cytokeratin-18 • serum • placenta • immunohistochemistry


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