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Journal of the Society for Gynecologic Investigation
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Composition of the Extracellular Matrix of the Peritoneum

Craig A. Witz, MD

Departments of Obstetrics and Gynecology, Cellular and Structural Biology and Internal Medicine, The University of Texas Health Science Center at San Antonio, San Antonio, Texas; Division of Reproductive Endocrinology and Infertility, Department of Obstetrics and Gynecology, Mail Code 7836, The University of Texas Health Science Center at San Antonio, 7703 Floyd Curl Drive, San Antonio, TX 78229-3900; witz{at}uthscsa.edu

Iris A. Montoya-Rodriguez, BS

Sook Cho, MD, PhD

Victoria E. Centonze, PhD

Lynda F. Bonewald, PhD

Robert S. Schenken, MD

Departments of Obstetrics and Gynecology, Cellular and Structural Biology and Internal Medicine, The University of Texas Health Science Center at San Antonio, San Antonio, Texas

Objective: To localize the extracellular matrix proteins collagen I, collagen IV, fibronectin, and laminin in the peritoneal membrane.

Study Design: Peritoneal biopsies (n = 13) from the anterior abdominal wall and the uterine serosa (n = 3) were incubated with antibodies to collagen IV, laminin, collagen I, and fibronectin. Specimens were examined using light and confocal laser scanning microscopy.

Results: All of the extracellular matrix (ECM) proteins were present immediately under the mesothelium. Collagen (Col) IV and laminin (LM) were seen in the smooth muscle of microvascular structures, in the subendothelial basement membrane, and were present in a fascicular pattern in the peritoneal stroma. Collagen I was distributed diffusely in the peritoneal stroma. Fibronectin was also present in the subendothelial basement membrane.

Conclusions: The resolution of the confocal microscope allowed for localization of extracellular matrix proteins in relation to the mesothelium. The presence of collagen IV, laminin, collagen I, and fibronectin under the mesothelium suggests that cells invading the peritoneum must have the ability to degrade and remodel this matrix.

Key Words: Peritoneum • collagen • fibronectin • laminin • endometriosis • cancer metastasis • confocal microscopy

Journal of the Society for Gynecologic Investigation, Vol. 8, No. 5, 299-304 (2001)
DOI: 10.1177/107155760100800508
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