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Journal of the Society for Gynecologic Investigation
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Expression of Soluble Adhesion Molecules in Sera of Women With Stage III and IV Endometriosis

Breton F. Barrier, MD

Department of Obstetrics and Gynecology, University of Missouri, Columbia, Missouri; Department of Obstetrics and Gynecology, Wilford Hall Medical Center, 2200 Bergquist Drive, Suite 1, Lackland AFB, TX 78236; breton.barrier{at}lackland.af.mil

Kathy L. Sharpe-Timms, PhD

Department of Obstetrics and Gynecology, University of Missouri, Columbia, Missouri

Objective: To determine the effect os stage III and IV endometriosis on serum concentration of soluble intracellular adhesion molecule-1 (ICAM-1), vascular cellular adhesion molecule-1 (VCAM-1), and E-selectin.

Methods: Sera from women with laparoscopically proven stage III and IV endometriosis were analyzed for the presence of soluble ICAM-1, VCAM-1, and E-selectin using enzyne-linked immunosorbent assays. Concentrations of these molecules were compared with those of laparoscopically proven disease-free controls.

Results: When compared with controls, women with stage III and IV endometriosis had higher serum concentration of soluble E-selectin.

Conclusion: Significant aberrations in levels of circulating adhesion molecules were found in women with stage III and IV endometriosis. These findings might shed light on the pathogenesis of endometriosis and be useful in the development of biochemical markers for disease stage.

Key Words: Endometriosis • soluble cell adhesion molecules • VCAM-1 • ICAM-1 • E-selectin • serum • marker

Journal of the Society for Gynecologic Investigation, Vol. 9, No. 2, 98-101 (2002)
DOI: 10.1177/107155760200900209
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