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Journal of the Society for Gynecologic Investigation
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Comparison of the Responses to Thrombin in Monkey Renal and Uterine Arteries

Toshio Kimura, MD, PhD

Kazuhide Ayajiki, MD, PhD

Yoichi Noda, MD, PhD

Tomio Okamura, MD, PhD

Departments of Obstetrics and Gynecology, and Pharmacology, Shiga University of Medical Science, Ohtsu, Japan

Objective: Thrombin is known to regulate vascular tone. We analyzed and compared mechanisms of thrombin action in primate renal and uterine arteries.

Results: Renal arteries responded to thrombin with relaxation, which was inhibited by NG-nitro-L-arginine or indomethacin and resersed to contractions by the combination. The relxations were also resersed to contractions by endohelial denudation. Conversely, thrombin caused uterine arterial contradictions that were unaffected by endothelial denudation. Relations in both renal arteries and contractions in uterine arteries were suppressed by hirudin (a specific thrombin inhibitor). Relaxant response to A23187 (Ca2+ ionophore), nitroprusside sodium (nitric oxide donor), and beraprost sodium (prostacyclin analogue) did not differ between renal and uterine arteries.

Conclusion: Thrombin-induced relaxation of renal artieries appears to be mediated by nitric oxide and vasodilaor prostaglandins liberated from the endothelium, whereas uterine arterial contraction is caused by an endothelium-independent mechanism.

Key Words: Thrombin • endothelium-derived nitric oxide • prostacyclin • renal artery • uterine artery

Journal of the Society for Gynecologic Investigation, Vol. 9, No. 3, 146-151 (2002)
DOI: 10.1177/107155760200900305
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