Journal of the Society for Gynecologic Investigation

 

Advanced Search

Journal Navigation

Journal Home

Subscriptions

Archive

Contact Us

Table of Contents

http://mc.manuscriptcentral.com/rsci

Click here to sign up for SAGE Journal Email Alerts today!

Sign In to gain access to subscriptions and/or personal tools.
This Article
Right arrow Full Text (PDF)
Right arrow References
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to Saved Citations
Right arrow Download to citation manager
Right arrowRequest Permissions
Right arrow Request Reprints
Right arrow Add to My Marked Citations
Citing Articles
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Silver, H. M.
Right arrow Articles by Canick, J. A.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Silver, H. M.
Right arrow Articles by Lambert-Messerlian, G. M.
Right arrow Articles by Reis, F. M.
Right arrow Articles by Diblasio, A. M.
Right arrow Articles by Petraglia, F.
Right arrow Articles by Canick, J. A.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us   Add to Digg   Add to Reddit   Add to Technorati  
What's this?
Journal of the Society for Gynecologic Investigation, Vol. 9, No. 5, 308-312 (2002)
DOI: 10.1177/107155760200900509

Mechanism of Increased Maternal Serum Total Activin A and Inhibin A in Preeclampsia

Helayne M. Silver, MD

Division of Maternal Fetal Medicine, Department of Obstetrics and Gynecology, and Department of Pathology, Brown University, Providence, Rhode Island; Department of Obstetrics and Gynecology University of Udine, Udine, Italy; Molecular Biology Laboratory, Istituto Auxologico Italiano, Milan, Italy; Women and Infants' Hospital of Rhode Island, 101 Dudley Street, Providence, RI 02905 hsilver{at}wihri.org

Garalyn M. Lambert-Messerlian, PhD

Fernando M. Reis, MD, PhD

Anna Maria Diblasio, MD

Felice Petraglia, MD

Jacob A. Canick, PhD

Division of Maternal Fetal Medicine, Department of Obstetrics and Gynecology, and Department of Pathology, Brown University, Providence, Rhode Island; Department of Obstetrics and Gynecology University of Udine, Udine, Italy; Molecular Biology Laboratory, Istituto Auxologico Italiano, Milan, Italy

Objective: To determine whether increased levels of maternal serum total activin A and inhibin A in preeclampsia are related to total blood volume, urinary clearance, or placental production.

Study Design: Activin A and inhibin A levels were measured in preeclamptic subjects and matched normotensive gravidas. In a subset of preeclamptic subjects (n = 21) and controls (n = 30), we performed blood volume studies. In an overlapping subject of preeclamptic subjects (n = 56), creatinine clearance results were available. Placental tissue was obtained from six preeclamptics and matched normotensive gravida for analysis of activin A and inhibin A mRNA expression.

Results: Maternal serum levels of inhibin A but not activin A were significantly negatively correlated with blood volume in preeclampsia (r2 = .26, P = 0.17, and r2 = .02, P = .44, respectively). Levels of both proteins were negatively correlated to creatinine clearance (r2 = .29, P < .0001, and r2 = .15, P = .003, respectively). Placental mRNA expression for both the {alpha} and ßA subunits was increased in preeclampsia (P = .038 and .049, respectively).

Conclusion: Although placental mRNA expression of the subunits for both analytes is increased in preeclampsia, the increased levels of activin A appear to be more specifically a reflection of increased placental production than do the increased levels of inhibin A.

Key Words: Inhibin A • activin A • preeclampsia • gestational hypertension


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us   Add to Digg Digg   Add to Reddit Reddit   Add to Technorati Technorati    What's this?