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Journal of the Society for Gynecologic Investigation
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Tumor Necrosis Factor-{alpha} Promotor Polymorphisms and Endometriosis

Fritz Wieser, MD

Gerhild Fabjani

Clemens Tempfer, MD

Christian Schneeberger, PhD

Robert Zeillinger, PhD

Johannes C. Huber, MD, PhD

Deparment of Obstetrics and Gynecology, Division of Gynecological Endocrinology and Assisted Reproduction, Division of Gynecology and Obstetrics, University of Vienna, Vienna, Asutria

Rene Wenzl, MD

Department of Obstetrics and Gynecology, Division of Gynecological Endocrinology and Assisted Reproduction, University of Vienna, Waehringer Guertel 18-20, A-1090 Vienna, Austria rene.wenzl{at}akh-wien.ac.at

Objective: To explore whether having the mutant tumor necrosis factor (TNF)2 (G-308*A) and TNFA-A (G-238*A) alleles in the TNF-{alpha} gene promotor region is higher in women with endometriosis, we determined the respective genotype and allele frequencies in a retrospective case-control study.

Methods: Polymerase chain reaction was performed to identify the G-308A and G-238A promotor polymorphisms in 92 women with surgically and histologically confirmed endometriosis. A series of 69 healthy women without a history of endometriosis served as clinical controls.

Results: The allele frequnecies of the TNF2 polymorphism were 0.13 and 0.16 in women with endometriosis and in the control group, respectively, and the frequencies of the TNFA-A polymorphisms in women with endometrisosis and in the control group were 0.04 and 0.05, respectively, with no significant difference between the study and control groups. The TNF2 polymorphism was present in the homozygous form (TNF2/2) in 4.3% of women with endometriosis and in 2.9% of controls (P = .7). No TNFA-A homozygotes (TNFAA/A) were detected.

Conclusion: We studied TNF-{alpha} promotor gene variants among women with endometriosis and found that having the G-308A TNF-{alpha} and the G-238A TNF-{alpha} polymorphism was not associated with endometriosis in a white population.

Key Words: Endometriosis • TNF-{alpha} • polymorphism • cytokine • white population

Journal of the Society for Gynecologic Investigation, Vol. 9, No. 5, 313-318 (2002)
DOI: 10.1177/107155760200900510
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