Advanced Search

Journal Navigation

Journal Home

Subscriptions

Archive

Contact Us

Table of Contents

SAGETRACK

Sign In to gain access to subscriptions and/or personal tools.
Journal of the Society for Gynecologic Investigation
This Article
Right arrow Abstract Freely available
Right arrow Free Full Text (Free PDF) Free
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to Saved Citations
Right arrow Download to citation manager
Right arrowRequest Permissions
Right arrow Request Reprints
Right arrow Add to My Marked Citations
Citing Articles
Right arrow Citing Articles via Google Scholar
Right arrow Citing Articles via Scopus
Google Scholar
Right arrow Articles by Demirturk, F.
Right arrow Articles by Koseoglu, D. R.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Demirturk, F.
Right arrow Articles by Aytan, H.
Right arrow Articles by Caliskan, A. C.
Right arrow Articles by Aytan, P.
Right arrow Articles by Koseoglu, D. R.
Social Bookmarking
Add to CiteULike   Add to Complore   Add to Connotea   Add to Del.icio.us   Add to Digg   Add to Reddit   Add to Technorati   Add to Twitter  
What's this?

Effect of Peroxisome Proliferator—Activated Receptor-{gamma} Agonist Rosiglitazone on the Induction of Endometriosis in an Experimental Rat Model

Fazli Demirturk, MD

Department of Obstetrics and Gynecology, Gaziosmanpasa University, Tokat, Turkey; Government of Health Ankara Diskapi Education and Research Hospital, Third Internal Medicine Clinic, Ankara, Turkey; Department of Pathology, Gaziosmanpasa University, Tokat, Turkey

Hakan Aytan, MD

Department of Obstetrics and Gynecology, Gaziosmanpasa University, Tokat, Turkey; Government of Health Ankara Diskapi Education and Research Hospital, Third Internal Medicine Clinic, Ankara, Turkey; Department of Pathology, Gaziosmanpasa University, Tokat, Turkeyv drhakanaytan{at}hotmail.com

Ahmet C. Caliskan, MD

Pelin Aytan, MD

Dogan R. Koseoglu, MD

Department of Obstetrics and Gynecology, Gaziosmanpasa University, Tokat, Turkey; Government of Health Ankara Diskapi Education and Research Hospital, Third Internal Medicine Clinic, Ankara, Turkey; Department of Pathology, Gaziosmanpasa University, Tokat, Turkey

Objective: To assess the effect of the peroxisome proliferator-activated receptor (PPAR)-{gamma} agonist rosigliotazone on the induction of endometriosis in a rat model.

Methods: Endometriosis was surgically induced in 28 rats by transplanting an autologous fragment of endometrial tissue onto the inner surface of the abdominal wall. Group I was assigned as control and no medication was administered. Starting 3 days before the operation and continuing for 4 weeks, 0.2 mg/kg/d rosiglitazone was administered to the study group orally. Four weeks later rats were killed and ectopic uterine tissues were evaluated morphologically and histologically. Scoring systems were used to evaluate preservation of epithelia.

Results: Four rats in the study group and one rat in the control group died of complications related to surgery. There was a significant difference in post-treatment spherical volumes (64.00 mm3 [interquartile range (IQR): 354.42] vs 41.60 mm3 [IQR: 37.87], P = .018) and explant weights (77.97 mg [IQR: 431.27] vs 47.24 mg [IQR: 43.01], P = .005) between control and rosiglitazone-treated groups. The epithelia were found to be preserved significantly better in the control group when compared with the roziglitazone-treated group (2.00 [IQR:2.00] vs 0.00 [IQR:2.25], P = .014).

Conclusions: Rosiglitazone was found to affect the induction of endometriosis negatively in this experimental rat model and seemed to interfere with the growth and maintenance of the uterine explant.

Key Words: Rosiglitazone • experimental endometriosis model • rat • peroxisome proliferator-activated receptor

References

  • 1. Strathy JH, Molgaard CA, Coulman CB. Endometriosis and infertility: A laparoscopic study of endometriosis among fertile and infertile women. Fertil Steril 1982;38:667-672.[Web of Science][Medline] [Order article via Infotrieve]
  • 2. Rice VM. Conventional medical therapies for endometriosis. Ann N Y Acad Sci 2002;955:343-352.[Web of Science][Medline] [Order article via Infotrieve]
  • 3. Sampson J. Periotneal endometriosis is due to the menstrual dissemination of endometrial tissue into the peritoneal cavity. Am J Obstet Gynecol 1927;14:433-469.
  • 4. Halme J, Hammond MG, Hulka JF, Raj SG, Talbert LM., Retrograde menstruation in healthy women and in patients with endometriosis. Obstet Gynecol 1984;64:151-154.[Web of Science][Medline] [Order article via Infotrieve]
  • 5. Malinak LR, Buttram VC Jr, Elias S. Heritable aspects of endometriosis. Hum Reprod 1980;6:544-549.
  • 6. Dmowski WP, Gebel HM, Braun DP. The role of cell-mediated immunity pathogenesis of endometriosis. Acta Obstet Gynecol Scand 1994;15:7-14.
  • 7. Halme J, White C, Kauma S, Estes J, Haskill S. Periotneal macrophages from patients with endometriosis release growth factor activity in vitro. J Clin Endocrinol Metabol 1988;66:1044-1049.[Abstract/Free Full Text]
  • 8. Halme J, Becker S, Haskill S. Altered maturation and function of peritoneal macrophages: Possible role in pathogenesis of endometriosis. Am J Obstet Gynecol 1987;156:783-789.[Web of Science][Medline] [Order article via Infotrieve]
  • 9. Harada T, Yoshioka H, Yoshida S, et al. Increased interleukin-6 levels in periotoneal fluid of infertile patients with active endometriosis. Am J Obstet Gynecol 1997;176:593-597.[CrossRef][Web of Science][Medline] [Order article via Infotrieve]
  • 10. Harada T, Enatsu A, Mitsunari M, et al. Role of cytokines in progression of endometriosis. Gynecol Obstet Invest 1999;47 Suppl 1:34-39.[CrossRef][Web of Science][Medline] [Order article via Infotrieve]
  • 11. Taylor RN, Ryan IP, Moore ES, Hornung D, Shifren JL, Tseng JF. Angiogenesis and macrophage activation in endometriosis. Ann NY Acad Sci 1997;828:194-207.[Web of Science][Medline] [Order article via Infotrieve]
  • 12. Ricote M, Huang JT, Welch JS, Glass CK. The peroxisome proliferator-activated receptor (PPAR-{gamma}) as a regulator of monocyte/macrophage function. J Leukoc Biol 1999;66:733-739.[Abstract]
  • 13. Vernon MW, Wilson EA. Studies on the surgical induction of endometriosis in the rat. Fertile Steril 1985;44:684-694.
  • 14. Lebovic DI, Kir M, Casey CL. Peroxisome proliferator-activated receptor-gamma induces regression of endometrial explants in a rat model of endometriosis. Fertil Steril 2004;82 Suppl 3:1008-1013.[CrossRef][Web of Science][Medline] [Order article via Infotrieve]
  • 15. Garcia-Velasco JA, Arici A, Zreik T, et al. Macrophage derived growth factors modulate Fas ligand expression in cultured endometrial stromal cells; A role in endomentriosis. Mol Hum Reprod 1999;5:642-650.[Abstract/Free Full Text]
  • 16. Lebovic DI, Bentzien F, Chao VA, Garrett EN, Meng YG, Taylor RN. Induction of an angiogenic phenotype in endometriotic stromal cell cultures by interleukin-1ß. Mol Hum Reprod 2000;6:2690-2675.
  • 17. Eisermann J, Gast MJ, Pineda J, et al. Tumor necrosis factor in peritoneal fluid of women undergoing laparoscopic surgery. Fertil Steril 1988;50:573-579.[Web of Science][Medline] [Order article via Infotrieve]
  • 18. Hill JA, Anderson DJ. Lymphocyte activity in the presence of periotoneal fluid from fertile women and infertile women with and without endometriosis. Am J Obstet Gynecol 1989;161:861-864.[Web of Science][Medline] [Order article via Infotrieve]
  • 19. Surrey ES, Halme J. Effect of platelet-derived growth factor on endomentrial stromal cell proliferation in vitro: A model for endometriosis? Fertil Steril 1991;56:672-679.[Web of Science][Medline] [Order article via Infotrieve]
  • 20. Rier SE, Zarmakoupis PN, Hu X, et al. Dysregulation of interleukin-6 responses in ectopic endometrial stromal cells: Correlation with decreased soluble receptor levels in peritoneal fluid of women with endometriosis. J Clin Endocrinol Metab 1995;80:1431-1437.[Abstract]
  • 21. Ryan IP, Schriock ED, Taylor RN. Isolation, characterization, and comparison of human endometrial and endometriosis cells in vitro. J Clin Endocrinol Metab 1994;78:642-649.[Abstract]
  • 22. Arici A, MacDonald Pc, Casey ML. Regulation of monocyte chemotactic prostein-1 gene expression in human endometrial cells in culture. Mol Cell Endocrinol 1995;107:189-197.[CrossRef][Web of Science][Medline] [Order article via Infotrieve]
  • 23. Hornung D, Dohrn K, Sotlar K, et al. Localization in tissues and secretion of eotaxin by cells from normal endometrium and endometriosis. J Clin Endocrinol Metab 2000;85:2604-2608.[Abstract/Free Full Text]
  • 24. Klein NA, Pergola GM, Tekmal RR. et al. Cytokine regulation of cellular proliferation in endometriosis. Ann N Y Acad Sci 1994;734:322-332.[Web of Science][Medline] [Order article via Infotrieve]
  • 25. Ricote M, Li AC, Willson TM, Kelly CJ, Glass CK. The peroxisome prliferator-activated receptor-{gamma} is a negative regulator of macrophage activation. Nature 1998;391:79-82.[CrossRef][Medline] [Order article via Infotrieve]
  • 26. Jiang C, Ting AT, Seed B. PPAR-{gamma} agonists inhibit production of monocyte inflammatory cytokines. Nature 1998;391:82-86.[CrossRef][Medline] [Order article via Infotrieve]
  • 27. Singer CF, Marbaix E, Kokorine I, et al. Paracrine stimulation of interstitial collagenase (MMP-1) in the human endometrium by interleukin 1alpha and its dual block by ovarian steroids. Proc Natl Acad Sci U S A 1997;94:10341-10345.[Abstract/Free Full Text]
  • 28. Rana N, Braun DP, House R, Gebel H, Rotman C, Dmowski WP. Basal and stimulated secretion of cytokines by peritoneal macrophages in women with endometriosis. Fertil Steril 1996;65:925-930.[Web of Science][Medline] [Order article via Infotrieve]
  • 29. Gazvani MR, Christmas S, Quenby S, Kirwan J, Johnson PM, Kingland CR. Peritoneal fluid concentrations of interleukin-8 in women with endometriosis: Relationship to stage of disease. Hum Reprod 1998;13:1957-1961.[Abstract/Free Full Text]
  • 30. Lebovic DI, Baldocchi RA, Mueller MD, Taylor RN. Altered expression of a cell-cycle suppressor gene, Tob-1, in endometriotic cells by cDNA array analyses. Fertil Steril 2002;78:849-854.[CrossRef][Web of Science][Medline] [Order article via Infotrieve]
  • 31. Arici A, Oral E, Attar E, Tazuke SI, Olive DL. Monocyte chemotactic protein-1 concentration in peritoneal fluid of women with endomentrisois and its modulation of expression in mesothelial cells. Fertil Steril. 1997;67:1065-1072.[CrossRef][Web of Science][Medline] [Order article via Infotrieve]
  • 32. Yee LD, Sabourin CL, Liu L,et al. Peroxisome proliferator-activated receptor gamma activation in human breast cancer. Int J Oncol 1999;15:967-973.[Web of Science][Medline] [Order article via Infotrieve]
  • 33. Houston KD, Copland JA, Broaddus RR, Gottardis MM, Fischer SM, Walker CL. Inhibition of proliferation and estrogen receptor signaling by peroxisome proliferator-activated recetor gamma ligands in uterine leiomyoma. Cancer Res 2003;63:1221-1227.[Abstract/Free Full Text]
  • 34. Heaney AP, Fernando M, Melmed S. PPAR-gamma receptor ligands: Novel therapy for pituitary adenomas. J Clin Invest 2003;111:1381-1388.[CrossRef][Web of Science][Medline] [Order article via Infotrieve]
  • 35. Sharpe KL, Zimmer RL, Khan RS, Penney LL. Proliferative and morphogenic changes induced by the coculture of rat uterine and perioneal cells: A cell culture model for endometriosis. Fertil Steril 1992;58:1220-1229.[Web of Science][Medline] [Order article via Infotrieve]
  • 36. Sharpe KL, Zimmer RL, Griffin WT, Penney LL. Polypeptides synthesized and released by human endometriosis differ from those of the uterine endometrium in cell and tissue explant culture. Fertil Steril 1993;60:839-851.[Web of Science][Medline] [Order article via Infotrieve]
  • 37. Isaacson KB, Xu Q, Lyttle CR. The effect of estradiol on the production and secretion of complement component 3 by the rat uterus and surgically induced endometriotic tissue. Fertil Steri. 1991;55:395-402.

Journal of the Society for Gynecologic Investigation, Vol. 13, No. 1, 58-62 (2006)
DOI: 10.1016/j.jsgi.2005.10.002
Add to CiteULike CiteULike   Add to Complore Complore   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us   Add to Digg Digg   Add to Reddit Reddit   Add to Technorati Technorati   Add to Twitter Twitter    What's this?



This Article
Right arrow Abstract Freely available
Right arrow Free Full Text (Free PDF) Free
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to Saved Citations
Right arrow Download to citation manager
Right arrowRequest Permissions
Right arrow Request Reprints
Right arrow Add to My Marked Citations
Citing Articles
Right arrow Citing Articles via Google Scholar
Right arrow Citing Articles via Scopus
Google Scholar
Right arrow Articles by Demirturk, F.
Right arrow Articles by Koseoglu, D. R.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Demirturk, F.
Right arrow Articles by Aytan, H.
Right arrow Articles by Caliskan, A. C.
Right arrow Articles by Aytan, P.
Right arrow Articles by Koseoglu, D. R.
Social Bookmarking
Add to CiteULike   Add to Complore   Add to Connotea   Add to Del.icio.us   Add to Digg   Add to Reddit   Add to Technorati   Add to Twitter  
What's this?