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Reproductive Sciences
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Endothelium-Dependent Vasodilatation in Formerly Preeclamptic Women Correlates Inversely With Body Mass Index and Varies Independently of Plasma Volume

Tessa Lommerse, MD

Department of Obstetrics and Gynecology, University of Maastricht, Maatricht, The Netherlands

Robert Aardenburg, MD

Department of Obstetrics and Gynecology, University of Maastricht, Maatricht, The Netherlands, robert{at}aardenburg.org

Alphons Houben, PhD

Department of Internal Medicine, University of Maastricht, Maastricht, The Netherlands

Louis L. Peeters, MD, PhD

Department of Obstetrics and Gynecology, University of Maastricht, Maatricht, The Netherlands

Endothelial dysfunction and a subnormal plasma volume predispose to preeclampsia. The authors determine whether endothelium-dependent vasodilatation is lower in formerly preeclamptic women, explore whether endothelial dysfunction coincides with low plasma volume, and determine if endothelial dysfunction correlates with circulating endothelial stressors. In formerly preeclamptic women and controls, the authors estimated changes in forearm blood flow after arterial occlusion. They measured plasma volume, blood pressure, and circulating variables. To identify factors associated with endothelial function, the authors used Spearman correlation and regression analysis. Endothelial function did not differ between patients and controls and did not correlate with plasma volume; however, it did correlate negatively with body mass index and positively with arterial compliance. Analysis suggested a negative impact of metabolic syndrome on endothelial function. In formerly preeclamptic women, endothelial function is comparable to controls and varies independently of plasma volume. In patients, endothelial function does vary with features of the metabolic syndrome.

Key Words: Preeclampsia • plasma volume • endothelial function.

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Reproductive Sciences, Vol. 14, No. 8, 765-770 (2007)
DOI: 10.1177/1933719107308336
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This Article
Right arrow Abstract Freely available
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Citing Articles
Right arrow Citing Articles via Google Scholar
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Google Scholar
Right arrow Articles by Lommerse, T.
Right arrow Articles by Peeters, L. L.
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PubMed
Right arrow PubMed Citation
Right arrow Articles by Lommerse, T.
Right arrow Articles by Aardenburg, R.
Right arrow Articles by Houben, A.
Right arrow Articles by Peeters, L. L.
Right arrowPubmed/NCBI databases
Medline Plus Health Information
*High Risk Pregnancy
Social Bookmarking
Add to CiteULike   Add to Complore   Add to Connotea   Add to Del.icio.us   Add to Digg   Add to Reddit   Add to Technorati   Add to Twitter  
What's this?