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Reproductive Sciences
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Type-Specific Antiviral Antibodies to Genital Human Papillomavirus Types in Mothers and Newborns

Kurt Heim, MD

Department of Obstetrics and Gynecology, Medical University, Innsbruck,Austria, heim_kurt{at}yahoo.com

Gernot Hudelist, MD

Department of Obstetrics and Gynecology, General Hospital,Villach,Austria, Department of Obstetrics and Gynecology, Division of Special Gynecology, Medical University Vienna, Austria

Andrea Geier, MD

Department of Obstetrics and Gynecology, Medical University, Innsbruck,Austria

Hannes Szedenik, MD

Department of Obstetrics and Gynecology, Medical University, Innsbruck,Austria

Neil D. Christensen, PhD

The Jake Gittlen Cancer Research Foundation, Department of Pathology, Milton S. Hershey Medical Center, Pennsylvania State University, Hershey

Nicole Concin, MD

Department of Obstetrics and Gynecology, Medical University, Innsbruck,Austria

Anton Bergant, MD

Department of Obstetrics and Gynecology, Medical University, Innsbruck,Austria

Birgit Volgger, MD

Department of Obstetrics and Gynecology, Medical University, Innsbruck,Austria

Klaus Czerwenka, MD

Department of Clinical Pathology, Division of Gynecopathology, Medical University Vienna, Austria

Reinhard Höpfl, MD

Department of Dermatolgy and Venerology, Medical University, Innsbruck, Austria

Type-specific antibodies to human papillomaviruses (HPVs) can be detected in most infected adult patients, and they have virus-neutralizing properties. However, there is a dearth of information on the seroprevalence of maternal and neonatal antibodies to HPV capsid antigens. Sera from 104 mothers, their newborns, and 3 twin pregnancies were analyzed by an enzyme-linked immunosorbent assay (ELISA) for the presence of specific IgG, IgM, and IgA antibodies to virus-like particles of HPV-6, -11, -16, -18, and -31. Maternal IgG positivity rates to HPV types 6, 11, 16, 18, and 31 were 23.1%, 2.9%, 8.7%, 5.8%, and 9.6%, respectively. Neonatal rates did not differ significantly, and individual IgG ELISA values of mothers and their infants and all paired twins showed a very high correlation. In contrast, nearly all IgM and IgA individual values in newborns were designated negative, whereas mothers' positivity rates ranged as high as 19.2%. Infants showed no HPV-related lesions at birth or at 4-year follow-up. Seven of 8 tested children lost IgG HPV antibodies in a follow-up examination. Similar anti-HPV IgG seropositivity in mothers and newborns and a lack of neonatal IgA and IgM together with twin and follow-up results indicate that neonatal IgG is not a sign of intrauterine HPV infection but, rather, maternofetal antibody transmission.

Key Words: Antibody • human papillomavirus • virus-like particle • serology • capsid • mother • newborn • fetus • neonate • maternofetal transmission

References

Reproductive Sciences, Vol. 14, No. 8, 806-814 (2007)
DOI: 10.1177/1933719107309546
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This Article
Right arrow Abstract Freely available
Right arrow Free Full Text (Free PDF) Free
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to Saved Citations
Right arrow Download to citation manager
Right arrowRequest Permissions
Right arrow Request Reprints
Right arrow Add to My Marked Citations
Citing Articles
Right arrow Citing Articles via Google Scholar
Right arrow Citing Articles via Scopus
Google Scholar
Right arrow Articles by Heim, K.
Right arrow Articles by Höpfl, R.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Heim, K.
Right arrow Articles by Hudelist, G.
Right arrow Articles by Geier, A.
Right arrow Articles by Szedenik, H.
Right arrow Articles by Christensen, N. D.
Right arrow Articles by Concin, N.
Right arrow Articles by Bergant, A.
Right arrow Articles by Volgger, B.
Right arrow Articles by Czerwenka, K.
Right arrow Articles by Höpfl, R.
Social Bookmarking
Add to CiteULike   Add to Complore   Add to Connotea   Add to Del.icio.us   Add to Digg   Add to Reddit   Add to Technorati   Add to Twitter  
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