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Reproductive Sciences
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The Effect of Maternal Body Condition Score Before and During Pregnancy on the Glucose Tolerance of Adult Sheep Offspring

Roselle L. Cripps, PhD

Department of Clinical Biochemistry, University of Cambridge, Cambridge, UK, rlc34{at}cam.ac.uk

Lucy R. Green, PhD

Institute of Developmental Sciences, Southampton General Hospital, Southampton, UK

John Thompson, HND

The Royal Veterinary College, Hertfordshire, UK

Malgorzata S. Martin-Gronert, BSc

Department of Clinical Biochemistry, University of Cambridge, Cambridge, UK

Melanie Monk

Department of Clinical Biochemistry, University of Cambridge, Cambridge, UK

I. Martin Sheldon, PhD

Mark A. Hanson, DPhil

Institute of Developmental Sciences, Southampton General Hospital, Southampton, UK

C.N. Hales, PhD

Department of Clinical Biochemistry, University of Cambridge, Cambridge, UK

Susan E. Ozanne, PhD

Department of Clinical Biochemistry, University of Cambridge, Cambridge, UK

This study investigates the effects of diet-induced changes in maternal body condition on glucose tolerance in sheep. Welsh Mountain ewes were established, by dietary manipulation, at a body condition score of 2 (lower body condition [LBCS], n = 17) or >3 (higher body condition [HBCS], n = 19) prior to and during pregnancy. Birth weight and postnatal growth were similar in LBCS and HBCS offspring. In young adulthood, LBCS offspring had increased fasting glucose levels (3.8 ± 0.07 vs 3.6 ± 0.05 mM, P < .05), poorer glucose tolerance (2274 ± 22.6 vs 2161 ± 33 min/mM, P < .01), and reduced insulin secretion (0.58 ± 0.05 vs 0.71 ± 0.07 nM/min, P = .07). Increased fasting glycemia, mild glucose intolerance, and impaired initial insulin secretory response, as observed in LBCS offspring, are indictors of increased diabetes risk in humans. These findings suggest that altered maternal body composition and an imbalance between the fetal and postnatal environment influence offspring glucose tolerance.

Key Words: Developmental programming • type 2 diabetes • maternal body composition.

This version was published on May 1, 2008

Reproductive Sciences, Vol. 15, No. 5, 448-456 (2008)
DOI: 10.1177/1933719107312161
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