Advanced Search

Journal Navigation

Journal Home

Subscriptions

Archive

Contact Us

Table of Contents

SAGETRACK

Sign In to gain access to subscriptions and/or personal tools.
Reproductive Sciences
This Article
Right arrow Full Text (PDF)
Right arrow All Versions of this Article:
1933719108317581v1
15/7/678    most recent
Right arrow References
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to Saved Citations
Right arrow Download to citation manager
Right arrowRequest Permissions
Right arrow Request Reprints
Right arrow Add to My Marked Citations
Citing Articles
Right arrow Citing Articles via Google Scholar
Right arrow Citing Articles via Scopus
Google Scholar
Right arrow Articles by Byun, H.-S.
Right arrow Articles by Jeung, E.-B.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Byun, H.-S.
Right arrow Articles by Lee, G.-S.
Right arrow Articles by Lee, B.-M.
Right arrow Articles by Hyun, S.-H.
Right arrow Articles by Choi, K.-C.
Right arrow Articles by Jeung, E.-B.
Social Bookmarking
Add to CiteULike   Add to Complore   Add to Connotea   Add to Del.icio.us   Add to Digg   Add to Reddit   Add to Technorati   Add to Twitter  
What's this?

Implantation-Related Expression of Epidermal Growth Factor Family Molecules and Their Regulation by Progesterone in the Pregnant Rat

Hyuk-Soo Byun, DVM

Laboratory of Veterinary Biochemistry and Molecular Biology, College of Veterinary Medicine, Chungbuk National University, Cheongju, Chungbuk, Republic of Korea

Geun-Shik Lee, DVM, PhD

Laboratory of Veterinary Biochemistry and Molecular Biology, College of Veterinary Medicine, Chungbuk National University, Cheongju, Chungbuk, Republic of Korea

Bo-Mi Lee, MS

Laboratory of Veterinary Biochemistry and Molecular Biology, College of Veterinary Medicine, Chungbuk National University, Cheongju, Chungbuk, Republic of Korea

Sang-Hwan Hyun, DVM, PhD

Laboratory of Veterinary Biotechnology, College of Veterinary Medicine, Chungbuk National University, Cheongju, Chungbuk, Republic of Korea

Kyung-Chul Choi, DVM, PhD

Department of Obstetrics and Gynecology, Child and Family Research Institute, University of British Columbia,Vancouver, British Columbia, Canada

Eui-Bae Jeung, DVM, PhD

Laboratory of Veterinary Biochemistry and Molecular Biology, College of Veterinary Medicine, Chungbuk National University, Cheongju, Chungbuk, Republic of Korea, ebjeung{at}chungbuk.ac.kr

The uterine expressions of epidermal growth factor(EGF) family are examined to elucidate their exact role(s) in rat pregnancy. EGF and its receptors' (EGF-R) mRNA levels increased significantly at implantation after which their expression gradually decreased. Heparin-binding EGF (HB-EGF) and transforming growth factor-{alpha} (TGF-{alpha}) showed a modest expression at gestation day (GD), GD4 and GD3, respectively, but were much strongly expressed at mid-pregnancy.Amphiregulin (Areg) was strongly expressed around implantation (GD4) and at mid-pregnancy (GD12).Treatment of pregnant rats with RU486 at GD5 or GD8 blocked the expression of all the genes, and administration of immature rats with progesterone (P4) induced the uterine expression of all the genes except HB-EGF. In addition, HB-EGF,TGF-{alpha}, and Areg proteins in the uterine and glandular epitheliums may participate in mid-pregnancy. Taken together, all of these activities are likely to be controlled by P4 in the uterus of pregnant rats.

Key Words: Uterus • pregnancy • EGF family • amphiregulin.

This version was published on September 1, 2008

Reproductive Sciences, Vol. 15, No. 7, 678-689 (2008)
DOI: 10.1177/1933719108317581
Add to CiteULike CiteULike   Add to Complore Complore   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us   Add to Digg Digg   Add to Reddit Reddit   Add to Technorati Technorati   Add to Twitter Twitter    What's this?