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Induced Hyper and Hypo Amino Acidemia in the Ovine Fetus Near Term: Effects on Electrocortical Activity

Departments of Physiology and Pharmacology, University of Western Ontario

Shannon Hemstreet, BSc

Department of Obstetrics and Gynecology University of Western Ontario, London, Ontario, Canada

Brad Matushewski, MSc

Department of Obstetrics and Gynecology University of Western Ontario, London, Ontario, Canada

Jeremy D. McCallum, MSc

Department of Obstetrics and Gynecology University of Western Ontario, London, Ontario, Canada

Bryan S. Richardson, MD

Departments of Physiology and Pharmacology, University of Western Ontario, Department of Obstetrics and Gynecology University of Western Ontario, London, Ontario, Canada, brichar1{at}uwo.ca

Amino acid infusate (Primene) and insulin euglycemic (insulin + 10% dextrose) clamp techniques were used in the ovine fetus near term and the impact on the incidence of low-voltage and high-voltage electrocortical (ECOG) activities was determined. Fetal sheep were studied over a 2-hour control period and a subsequent 6-hour experimental period.With the Primene infusion, the basic and neutral amino acids were increased by 43% and 25%, respectively, whereas the acidic amino acids showed little change. With the insulin/dextrose infusion, the basic and neutral amino acids decreased by 48% and 30%, respectively, whereas the acidic amino acids were again little changed. A small fall in arterial oxygen saturation and an increase in fetal heart rate for both groups can be attributed to an insulin-mediated increase in fetal metabolic rate. Despite the moderate increases and decreases in circulating amino acid levels, there was no significant change in the mean percent time or duration of fetal ECOG activities for either study group.

Key Words: Fetal sheep • electrocortical activity • amino acids.

This version was published on September 1, 2008

Reproductive Sciences, Vol. 15, No. 7, 710-719 (2008)
DOI: 10.1177/1933719108317152


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