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Reproductive Sciences
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Article

Feasibility of Ultrasound-guided Percutaneous Samplings in the Pregnant Baboon: A Model for Studies on Transplacental Transport

Kristel Van Calsteren, MD*, Roland Devlieger, MD, PhD, Luc De Catte, MD, PhD, Thomas D'Hooghe, MD, PhD, Daniel Chai, DVM, Jason Mwenda, PhD, Ignace Vergote, MD, PhD, and Frederic Amant, MD, PhD

* To whom correspondence should be addressed. E-mail: kristel.vancalsteren{at}med.kuleuven.be.


  Abstract

Objective: A study was conducted to test the feasibility of cordocenteses and amniocenteses at different gestational ages in pregnant baboons. Study Design: Experiments were performed in 10 pregnant baboons at a median gestational age of 131 (range 92-169) days. At different time intervals, percutaneous samplings of amniotic fluid and fetal blood were performed under ultrasound guidance. Simultaneously, maternal blood samples were drawn. Results: With a median fetal weight of 431 g (range 111-690 g), 29 of 30 cordocenteses (96.6%) and all 30 amniocenteses and maternal samplings (100%) were successful in obtaining the required quantities for analysis. One cordocentesis was abandoned because of insufficient visualization of the umbilical cord due to a placental haemorrhage. Conclusion: Percutaneous amniocentesis and cordocentesis can be performed with a high success rate in the pregnant baboon model. In combination with a 100% success rate in obtaining simultaneous maternal blood samples, this method is able to provide data on transplacental transport.

First published on December 15, 2008, doi:10.1177/1933719108324890

Reproductive Sciences 2009;16:280.

A more recent version of this article appeared on March 1, 2009

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