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Reproductive Sciences
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Article

Role of Protein Kinase C{alpha} in Regulation of [Ca2+]1 and Force in Human Myometrium

Victor P. Fomin, PhD*, Andris Kronbergs, MS, Susan Gunst, PhD, Dale Tang, PhD, Vladimir Simirskii, PhD, Matthew Hoffman, MD, and Randall L. Duncan, PhD

* To whom correspondence should be addressed. E-mail: vfomin{at}udel.edu.


  Abstract

Recent findings implicate protein kinase C in regulation of contraction of uterine muscle (myometrium). However, the role of protein kinase C isoforms in myometrial contraction remains uncertain. Therefore, this study examined protein kinase C{alpha}’ concentration [Ca2+]1 of myometrium from term pregnant women. The authors demonstrated that protein kinase C{alpha} inhibitor Go6976 decreased the amplitude of potassium chloride–induced myometrial contractions in a time-dependent manner. The treatment of the myometrial strips with protein kinase C{alpha}– [Ca2+]1 response to 39.3% + 6.8% and 50.0% + 3.3%, respectively, compared to control. The sense oligonucleotides treatment did not significantly change the potassium chloride responses (89.8% +6.8% and 93.9%+4.5% of the control for the contraction and [Ca2+]1, respectively). These data, coupled with the observation that protein kinase C{alpha} levels are elevated in the pregnant myometrium, suggest the involvement of protein kinase C{alpha} in regulation of human uterine contraction.

First published on December 15, 2008, doi:10.1177/1933719108324892

Reproductive Sciences 2009;16:71.

A more recent version of this article appeared on January 1, 2009

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