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Reproductive Sciences
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Article

Na+,K+-ATPase Activity and Subunit Isoform Protein Abundance

Najma S. Mehter1, Grazyna B. Sadowska2, Shadi N. Malaeb2, and Barbara S. Stonestreet2*

1 Brown University School of Medicine; The Ohio State University
2 Brown University School of Medicine

* To whom correspondence should be addressed. E-mail: Bstonestreet{at}wihri.org.


  Abstract

We examined the effects of single and multiple maternal glucocorticoid courses on cerebral cortical (CC) and renal cortical (RC) Na+,K+-ATPase activity and protein isoform abundance in fetal sheep. Ewes received four dexamethasone or placebo injections in the single course (SC) groups, and the same treatment once a week for five-weeks in the multiple course (MC) groups. CC Na+,K+-ATPase {alpha}2-abundance was higher (P<0.05) and {beta}2-abundance lower in the SC dexamethasone than placebo group, but Na+,K+-ATPase activity did not change. CC Na+,K+-ATPase activity, {alpha}1-, {beta}1-, and {beta}2-abundance were lower in the MC dexamethasone than placebo group, but {alpha}2- and {alpha}3-abundance did not change. Both dexamethasone courses did not affect CC cell number. RC Na+,K+-ATPase activity, {alpha}1- and {beta}1-abundance were higher in the MC dexamethasone than placebo group, but did not change in the SC dexamethasone group. We conclude MC, but not a SC of dexamethasone, affect fetal cerebral and renal Na+,K+-ATPase, and MC result in differential effects on Na+,K+-ATPase in these organs.

First published on November 11, 2008, doi:10.1177/1933719108325507

Reproductive Sciences 2009;16:294.

A more recent version of this article appeared on March 1, 2009

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