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Reproductive Sciences
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1933719108327594v1
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Article

Plasma From Preeclamptic Women Stimulates Transendothelial Migration of Neutrophils

Scott W. Walsh*

* To whom correspondence should be addressed. E-mail: swwalsh{at}vcu.edu.


  Abstract

Neutrophils infiltrate systemic vasculature of women with preeclampsia, so we tested the hypothesis that factors in plasma of preeclamptic women activate endothelial cells to produce IL-8 resulting in transendothelial migration of neutrophils. Neutrophil migration was studied using the Transwell system. An endothelial cell line was grown to confluence on the inserts and treated with 10% plasma from normal nonpregnant (NNP), normal pregnant (NP) and preeclamptic (PE) women or with an oxidizing solution containing linoleic acid (OxLA). Compared to medium control, NNP plasma or NP plasma, PE plasma significantly stimulated IL-8 and neutrophil migration which was inhibited by vitamins E and C or IL-8 neutralizing antibody. Compared to medium control or LA, OxLA stimulated IL-8 and neutrophil migration which was inhibited by vitamins E and C or IL-8 antibody. Conclusion: Factors present in plasma of preeclamptic women stimulate transendothelial migration of neutrophils which is due to induction of oxidative stress and production of IL-8.

First published on December 15, 2008, doi:10.1177/1933719108327594

Reproductive Sciences 2009;16:320.

A more recent version of this article appeared on March 1, 2009

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 Reproductive SciencesHome page
L.K. Harris, O.H. Clancy, J.E. Myers, and P.N. Baker
Plasma From Women With Preeclampsia Inhibits Trophoblast Invasion
Reproductive Sciences, November 1, 2009; 16(11): 1082 - 1090.
[Abstract] [PDF]