Advanced Search

Journal Navigation

Journal Home

Subscriptions

Archive

Contact Us

Table of Contents

SAGETRACK

Sign In to gain access to subscriptions and/or personal tools.
Reproductive Sciences
This Article
Right arrow Full Text (OnlineFirst PDF)
Right arrow All Versions of this Article:
1933719108328609v1
1933719108328609v2
16/5/453    most recent
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to Saved Citations
Right arrow Download to citation manager
Right arrowRequest Permissions
Right arrow Request Reprints
Right arrow Add to My Marked Citations
Citing Articles
Right arrow Citing Articles via Google Scholar
Right arrow Citing Articles via Scopus
Google Scholar
Right arrow Articles by Arcuri, F.
Right arrow Articles by Lockwood, C. J.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Arcuri, F.
Right arrow Articles by Toti, P.
Right arrow Articles by Buchwalder, L.
Right arrow Articles by Casciaro, A.
Right arrow Articles by Cintorino, M.
Right arrow Articles by Schatz, F.
Right arrow Articles by Rybalov, B.
Right arrow Articles by Lockwood, C. J.
Right arrowPubmed/NCBI databases
*Gene*GEO Profiles
*HomoloGene*UniGene
*Compound via MeSH
*Substance via MeSH
Medline Plus Health Information
*High Risk Pregnancy
Social Bookmarking
Add to CiteULike   Add to Complore   Add to Connotea   Add to Del.icio.us   Add to Digg   Add to Reddit   Add to Technorati   Add to Twitter  
What's this?

Article

Mechanisms of Leukocyte Accumulation and Activation in Chorioamnionitis: Interleukin 1B and Tumor Necrosis Factor Enhance Colony Stimulating Factor 2 Expression in Term Decidua

Felice Arcuri, PhD, Paolo Toti, MD, Lynn Buchwalder, MS, Alessandra Casciaro, MS, Marcella Cintorino, MD, Frederick Schatz, PhD*, Basya Rybalov, PhD, and Charles J. Lockwood, MD

* To whom correspondence should be addressed. E-mail: frederick.schatz{at}yale.edu.


  Abstract

Chorioamnionitis is a major cause of prematurity as well as perinatal morbidity and mortality. The present study observed a marked increase in immunohistochemical staining for Colony Stimulating Factor 2 (CSF2; also known as granulocyte macrophage-colony stimulating factor), a potent neutrophil and macrophage chemoattractant and activator, in the decidua of patients with CAM compared with controls (n = 8; P = .001). To examine the regulation of this CSF2, cultured decidual cells primed with estradiol (E2) or E2 plus medroxyprogesterone acetate, were exposed to tumor necrosis factor-{alpha} or interleukin-1{beta} and secreted CSF2 measured by ELISA. Levels of CSF2 in E2 plus MPA-treated cultures increased 18- and 245-fold following treatment with TNF or IL1B (n = 7, P < .05). Quantitative RT-PCR demonstrated parallel changes in mRNA levels. This study reveals that CSF2 is strongly expressed in decidua from patients with CAM and indicates TNF or IL1B as important regulators of CAM-related decidual leukocyte infiltration and activation.

First published on January 22, 2009, doi:10.1177/1933719108328609

Reproductive Sciences 2009;16:453.

A more recent version of this article appeared on May 1, 2009
 This version was published on January 30, 2009
Add to CiteULike CiteULike   Add to Complore Complore   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us   Add to Digg Digg   Add to Reddit Reddit   Add to Technorati Technorati   Add to Twitter Twitter    What's this?