Advanced Search

Journal Navigation

Journal Home

Subscriptions

Archive

Contact Us

Table of Contents

SAGETRACK

Sign In to gain access to subscriptions and/or personal tools.
Reproductive Sciences
This Article
Right arrow Full Text (OnlineFirst PDF)
Right arrow All Versions of this Article:
1933719108328617v1
16/5/462    most recent
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to Saved Citations
Right arrow Download to citation manager
Right arrowRequest Permissions
Right arrow Request Reprints
Right arrow Add to My Marked Citations
Citing Articles
Right arrow Citing Articles via Google Scholar
Right arrow Citing Articles via Scopus
Google Scholar
Right arrow Articles by Gleicher, N.
Right arrow Articles by Barad, D.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Gleicher, N.
Right arrow Articles by Weghofer, A.
Right arrow Articles by Oktay, K.
Right arrow Articles by Barad, D.
Social Bookmarking
Add to CiteULike   Add to Complore   Add to Connotea   Add to Del.icio.us   Add to Digg   Add to Reddit   Add to Technorati   Add to Twitter  
What's this?

Article

Can the FMR1 (Fragile X) Gene Serve As Predictor of Response to Ovarian Stimulation?

Norbert Gleicher, MD*, Andrea Weghofer, MD, PhD, Kutluk Oktay, MD, and David Barad, MD, MS

* To whom correspondence should be addressed. E-mail: ykizawa{at}thechr.com.


  Abstract

Because triple CGG repeats on FMR1 correlate with anti-Müllerian hormone, repeats may also correlate with clinical outcomes. In 55 in vitro fertilization patients, repeats, corrected for gonadotropin dosage, were, therefore, correlated to oocytes. Patients were stratified by <35 and ≥35 repeats, and by age to <38 or ≥38 years. Less than 35 (but not ≥35) repeats demonstrated significantly lower anti-Müllerian hormone at ages ≥38 than at <38 years (P < .05). In >38 years, anti-Müllerian hormone was not affected by repeats. In <38 years, with <35 repeats (though not with ≥35), required significantly less gonadotropins than ≥38 (P < .05). In <38 years (though not ≥38), those with <35 repeats produced significantly more oocytes than women with ≥35 repeats (P = .006). In <38 years, retrieved oocytes were inversely related to repeats, adjusted for gonadotropin dosage (P = .03). This supports FMR1 testing as useful in fertility practice and suggests why response rates to increasing stimulation with gonadotropins may vary.

First published on December 30, 2008, doi:10.1177/1933719108328617

Reproductive Sciences 2009;16:462.

A more recent version of this article appeared on May 1, 2009

Add to CiteULike CiteULike   Add to Complore Complore   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us   Add to Digg Digg   Add to Reddit Reddit   Add to Technorati Technorati   Add to Twitter Twitter    What's this?