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Reproductive Sciences
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Article

Cellular Metabolism: Contribution to Postoperative Adhesion Development

Valerie Shavell, MD*, Ghassan Saed, PhD, and Michael Diamond, MD

* To whom correspondence should be addressed. E-mail: vshavell{at}med.wayne.edu.


  Abstract

Postoperative adhesions are a significant source of morbidity, including contributions to pelvic pain, bowel obstruction, and infertility. While the mechanisms of postoperative adhesion development are complex and incompletely understood, hypoxia appears to trigger a cascade of intracellular responses involving hypoxia-inducible factors, lactate, reactive oxygen species, reactive nitrogen species, and insulin-like growth factors that results in manifestation of the adhesion phenotype. Thus, substantial evidence exists to implicate the direct role of cellular metabolism in wound repair and adhesion development.

First published on March 16, 2009, doi:10.1177/1933719109332826

Reproductive Sciences 2009;16:627.

A more recent version of this article appeared on July 1, 2009

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