Advanced Search

Journal Navigation

Journal Home

Subscriptions

Archive

Contact Us

Table of Contents

SAGETRACK

Sign In to gain access to subscriptions and/or personal tools.
Reproductive Sciences
This Article
Right arrow Full Text (OnlineFirst PDF)
Right arrow All Versions of this Article:
1933719109334259v1
16/7/685    most recent
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to Saved Citations
Right arrow Download to citation manager
Right arrowRequest Permissions
Right arrow Request Reprints
Right arrow Add to My Marked Citations
Citing Articles
Right arrow Citing Articles via Google Scholar
Right arrow Citing Articles via Scopus
Google Scholar
Right arrow Articles by Haidopoulos, D.
Right arrow Articles by Antsaklis, A.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Haidopoulos, D.
Right arrow Articles by Partsinevelos, G. A.
Right arrow Articles by Vlachos, G. D.
Right arrow Articles by Rodolakis, A.
Right arrow Articles by Markaki, S.
Right arrow Articles by Voulgaris, Z.
Right arrow Articles by Diakomanolis, E.
Right arrow Articles by Antsaklis, A.
Social Bookmarking
Add to CiteULike   Add to Complore   Add to Connotea   Add to Del.icio.us   Add to Digg   Add to Reddit   Add to Technorati   Add to Twitter  
What's this?

Article

p16INK4A Is a Strong Biomarker for Cervical Intraepithelial Neoplasia and Invasive Cervical Carcinoma: A Reappraisal

Dimitrios Haidopoulos, MD, George A. Partsinevelos, MD*, George D. Vlachos, MD, Alexandros Rodolakis, MD, Sonia Markaki, MD, Zannis Voulgaris, MD, Emmanuel Diakomanolis, PhD, and Aris Antsaklis, PhD

* To whom correspondence should be addressed. E-mail: partsiobgyn{at}yahoo.com.


  Abstract

To assess the role of p16INK4A, bcl-2, and p53 in cervical cancer screening, we conducted a retrospective trial of prospectively collected data. Sixty two women with abnormal Pap smears were subjected to colposcopy and biopsies from any abnormal lesion. Human papillomavirus (HPV)-DNA typing, histology, and immunochemistry for p16INK4A, bcl-2, and p53 were performed for these women. Histologic diagnosis was that of low grade squamous intraepithelial lesion (LSIL), high grade squamous intraepithelial lesion (HSIL), or cancer in all cases. Human papillomavirus strains were identified in 56 patients (90.3%). All HSIL and invasive cancer cases were HPV positive. p16INK4A immunostaining yielded 100% sensitivity, 76% specificity, 61% positive predictive value, and 100% negative predictive value in cancer patients. The corresponding performance indicators for HSIL patients were 75%, 62%, 32%, and 91%. bcl-2 and p53 expression did not correlate with worsening grades of cervical disease. We conclude that p16INK4A seems to be a sensitive biomarker of high grade cervical intraepithelial neoplasia and cancer.

First published on April 16, 2009, doi:10.1177/1933719109334259

Reproductive Sciences 2009;16:685.

A more recent version of this article appeared on July 1, 2009

Add to CiteULike CiteULike   Add to Complore Complore   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us   Add to Digg Digg   Add to Reddit Reddit   Add to Technorati Technorati   Add to Twitter Twitter    What's this?